LINKAGE:A diagnostic test involving the study of several family members in order to determine the segregation pattern of the "at risk" locus. Many highly informative markers are now available for known disease genes. Many of these markers either flank or are intragenic to the disease gene locus and provide very accurate prediction of disease risk. In certain disorders, linkage studies provide the most accurate and cost-effective diagnostic testing as the disorder has significant mutation heterogeneity.
It must be appreciated that not all family structures are amenable to linkage studies. In addition, not all families will yield information with the known markers. Please consult with CompGene prior to sending samples for linkage studies.